LIPIDIC PEPTIDES .10. SYNTHESIS, STRUCTURAL AND PHYSICOCHEMICAL ELUCIDATION OF LIPIDIC AMINO-ACID CONJUGATES WITH HYDROPHILIC COMPOUNDS

被引：11

作者：

TOTH, I ^{[1
]}

ANDERSON, GJ ^{[1
]}

HUSSAIN, R ^{[1
]}

WOOD, IP ^{[1
]}

FERNANDEZ, ED ^{[1
]}

WARD, P ^{[1
]}

GIBBONS, WA ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

TETRAHEDRON | 1992年 / 48卷 / 05期

关键词：

AMINO ACIDS; FATTY; HYDROPHILIC CONJUGATION; DRUG DELIVERY; AGGREGATES;

D O I：

10.1016/S0040-4020(01)88194-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lipidic amino acids 1a, c and dimer 1b were coupled to highly hydrophilic compounds, latic, glycolic and gluconic acids and protected guloric acid, yielding conjugates 1d, f, h, i, j, k, 1 and o. After carboxyl deprotection, acids 1e, g and m and were obtained. Physico-chemical investigations of these compounds were carried out using proton nuclear magnetic resonance. Plots of chemical shift versus concentration revealed the formation of aggregates or micelles at high concentrations and monomers at low concentrations.

引用

页码：923 / 930

页数：8

共 11 条

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