CHARACTERIZATION OF AN EPIBODY - AN ANTIIDIOTYPE THAT REACTS WITH BOTH THE IDIOTYPE OF RHEUMATOID FACTORS (RF) AND THE ANTIGEN RECOGNIZED BY RF

被引：35

作者：

CHEN, PP

FONG, S

HOUGHTEN, RA

CARSON, DA

机构：

[1] SCRIPPS CLIN & RES FDN, DEPT BASIC & CLIN RES, LA JOLLA, CA 92037 USA

[2] SCRIPPS CLIN & RES FDN, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1985年 / 161卷 / 02期

关键词：

D O I：

10.1084/jem.161.2.323

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, an antiidiotype to human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors) was found to react also with human IgG. This peculiar antiidiotype was called an epibody. The induction of a similar epibody by immunization with a synthetic peptide (corresponding to 1 hypervariable region of the IgM-RF Glo) is described. The results confirm the existence of epibodies, and provide the possible molecular basis of the epibody phenomenon.

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页码：323 / 331

页数：9

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