SKIN LEVELS OF VASOACTIVE INTESTINAL POLYPEPTIDE IN ATOPIC-DERMATITIS

被引：20

作者：

PINCELLI, C ^{[1
]}

FANTINI, F ^{[1
]}

ROMUALDI, P ^{[1
]}

LESA, G ^{[1
]}

GIANNETTI, A ^{[1
]}

机构：

[1] UNIV BOLOGNA, INST PHARMACOL, I-40126 BOLOGNA, ITALY

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1991年 / 283卷 / 04期

关键词：

NEUROPEPTIDES; VASOACTIVE INTESTINAL POLYPEPTIDE; ATOPIC DERMATITIS; RADIOIMMUNOASSAY;

D O I：

10.1007/BF01106107

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioimmunologically in whole-tissue homogenates of lesional skin of 13 patients with atopic dermatitis. Radioimmunoassay was performed using an antiserum, AH78, recognizing the carboxy-terminal fragment vasoactive intestinal polypeptide (22-28). Vasoactive intestinal polypeptide immunoreactivity was detected in relatively low amounts in control skin (0.428 +/- 0.08 pmol/g tissue), whereas a marked increase in the peptide was observed in lesional skin of patients with atopic dermatitis (5.62 +/- 1.25 pmol/g tissue). These results seem to suggest that vasoactive intestinal polypeptide could have a pathogenetic relevance in skin lesions of atopic dermatitis.

引用

页码：230 / 232

页数：3

共 25 条

[1] PERIPHERAL VASCULAR RESPONSES IN ATOPIC DERMATITIS - INFLUENCE OF ENVIRONMENTAL TEMPERATURE CHANGES [J].