INHERITANCE OF RIBOSOMAL GENE ACTIVITY AND LEVEL OF DNA METHYLATION OF INDIVIDUAL GENE CLUSTERS IN A 3 GENERATION FAMILY

被引：25

作者：

DECAPOA, A

ALEIXANDRE, C

FELLI, MP

RAVENNA, L

COSTANTINO, MA

GIANCOTTI, P

VICENTI, O

POGGESI, I

GRAPPELLI, C

MILLER, DA

机构：

[1] UNIV SALAMANCA,FAC MED,DEPT BIOL CELULAR & PATOL,UNIDAD BIOL MED,SALAMANCA,SPAIN

[2] WAYNE STATE UNIV,SCH MED,FAC MED,DEPT MOLEC BIOL & GENET,DETROIT,MI 48201

来源：

HUMAN GENETICS | 1991年 / 88卷 / 02期

关键词：

D O I：

10.1007/BF00206062

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ribosomal gene activity and levels of DNA methylation were investigated by cytochemical and immunological methods in the nucleolar organizer regions (NORs) of individually recognised acrocentric chromosomes. Mendelian inheritance of ribosomal gene activity in a three generation family was demonstrated, together with consistent behaviour of individual gene clusters in different carriers, even when environmental conditions were changed. For most chromosomes, an inverse relationship between gene activity and the level of DNA methylation was observed. Exceptions were the two chromosomes 15 and chromosomes 13cp and 22p, all being strongly chromomycin-A3-positive in their short arms. These chromosomes bound to anti-5-MeC antibodies with differential frequencies in the different carriers. The possibility of involvement of repetitive GC-rich DNA in this behaviour is discussed.

引用

页码：146 / 152

页数：7

共 31 条

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