EXPEDITIOUS SYNTHESIS OF HIGHLY CYTOTOXIC 10-DECARBOXYQUINOCARCIN AND ITS 7-CYANO CONGENERS FROM QUINOCARCIN

被引：11

作者：

KATOH, T ^{[1
]}

KIRIHARA, M ^{[1
]}

YOSHINO, T ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 36期

关键词：

10-DECARBOXYQUINOCARCIN; QUINOCARCIN; CYTOTOXICITY; 2-THIOPYRIDON-1-YL ESTER; RADICAL DECARBOXYLATION;

D O I：

10.1016/S0040-4039(00)73851-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

10-Decarboxyquinocarcin and its 7-cyano congeners, which are 10-1000 times more cytotoxic than those of natural quinocarcin and its 7-cyano congeners, were efficiently synthesized from quinocarcin by utilizing the Barton radical decarboxylation.

引用

页码：5751 / 5752

页数：2

共 7 条

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[3]

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[4]

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[5]

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[7] CHIRAL SYNTHESIS OF THE ABC-RING SYSTEM OF QUINOCARCIN [J].

SAITO, S ;

TANAKA, K ;

NAKATANI, K ;

MATSUDA, F ;

TERASHIMA, S .

TETRAHEDRON LETTERS, 1989, 30 (52) :7423-7426

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