p53 immunoreactive stain and early colorectal adenocarcinomas

被引：11

作者：

Hirota, S

Kudo, S

Hosobe, S

Kobayashi, T

Himori, M

Ikeda, M

Takemoto, Y

Nomoto, M

Aoyagi, Y

Asakura, H

机构：

[1] AKITA RED CROSS HOSP,DEPT PATHOL,AKITA,JAPAN

[2] NIIGATA UNIV,DEPT INTERNAL MED 3,NIIGATA,JAPAN

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 13-14期

关键词：

p53; colorectum; early adenocarcinoma;

D O I：

10.1016/0959-8049(95)00348-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

565 cases of early colorectal adenocarcinomas were used in this study to examine mechanisms of carcinogenesis. Specimens were paraffin embedded and histological sections were stained with haematoxylin-eosin and p53. Macroscopically, early colorectal adenocarcinomas could be classified into two types: protruding and depressed. The former were composed of branching glands, while the latter were composed of straight glands which opened to the surface. The p53 positive ratio was similar for protruding tumours but was higher in depressed submucosal invasive adenocarcinomas than in depressed intramucosal adenocarcinomas. These results raise the possibility of at least two pathways for colorectal carcinogenesis, adenoma-carcinoma lesions and de novo carcinoma lesions.

引用

页码：2220 / 2222

页数：3