CALCITONIN GENE-RELATED PEPTIDE STIMULATES ADENYLATE-CYCLASE ACTIVITY IN TROUT GILL CELL-MEMBRANES

被引：17

作者：

FOUCHEREAUPERON, M ^{[1
]}

ARLOTBONNEMAINS, Y ^{[1
]}

MILHAUD, G ^{[1
]}

MOUKHTAR, MS ^{[1
]}

机构：

[1] CHU ST ANTOINE, CNRS, URA 174, F-75571 PARIS 12, FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90713-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physiological significance of calcitonin gene-related peptide (CGRP) was investigated by assessing the CGRP stimulated adenylate cyclase activity in various tissues of trout. The highest enzyme concentration was found in gill and stomach membranes. The maximal activity (190 % of the basal value) was observed for a concentration of 53.3 nM CGRP I or II. In the presence of 58 nM sCT, the maximal enzyme activity represented 120% of the basal value. No additive effect was observed; this suggests that both CGRP and sCT activities are mediated through the same receptor. The present data are in favour of a role for this neuropeptide operating in branchial cell functions such as calcium transfer from the external to the internal milieu. © 1990.

引用

页码：582 / 587

页数：6

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