THE USE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS TO PREVENT ADHERENCE OF STAPHYLOCOCCUS-EPIDERMIDIS TO MEDICAL POLYMERS

被引:55
作者
FARBER, BF
WOLFF, AG
机构
[1] Division of Infectious Diseases, Department of Medicine, North Shore University Hospital-Comeli University Medical College, Manhasset, NY
关键词
D O I
10.1093/infdis/166.4.861
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effect of salicylates and other nonsteroidal antiinflammatory drugs on the production of Staphylococcus epidermidis extracellular slime was studied. A dose-related decrease in slime production was observed with increasing concentrations of salicylic acid. S. epidermidis grown in 5 m-M salicylic acid were less likely to adhere to Silastic, polyvinyl chloride, polyurethane, and Teflon catheters (P < .006); strains grown in 2 mM salicylic acid, ibuprofen, indomethacin, or phenylbutazone were less adherent to Silastic catheters (P < .001). Similar results were obtained with polyurethane catheters. S. epidermidis strains were less likely to adhere (43%-82% inhibition) to polyurethane catheters treated with 500 mM salicylic acid diluted in ethanol (P < .0001). Similar differences were not observed with acetaminophen, ibuprofen, or acetylsalicylic acid. Adherence of radiolabeled S. epidermidis to salicylic acid-treated Silastic catheters demonstrated a dose-related reduction. The use of salicylic acid to coat medical devices may decrease the incidence of device-related infection.
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收藏
页码:861 / 865
页数:5
相关论文
共 20 条
[1]   THE MECHANISMS OF ACTION OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS [J].
ABRAMSON, SB ;
WEISSMANN, G .
ARTHRITIS AND RHEUMATISM, 1989, 32 (01) :1-9
[2]  
ARCHER GL, 1984, CURR CLIN TOP INFECT, V7, P25
[3]   ADHERENCE OF COAGULASE-NEGATIVE STAPHYLOCOCCI TO PLASTIC TISSUE-CULTURE PLATES - A QUANTITATIVE MODEL FOR THE ADHERENCE OF STAPHYLOCOCCI TO MEDICAL DEVICES [J].
CHRISTENSEN, GD ;
SIMPSON, WA ;
YOUNGER, JJ ;
BADDOUR, LM ;
BARRETT, FF ;
MELTON, DM ;
BEACHEY, EH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1985, 22 (06) :996-1006
[4]   CHARACTERIZATION OF CLINICALLY SIGNIFICANT STRAINS OF COAGULASE-NEGATIVE STAPHYLOCOCCI [J].
CHRISTENSEN, GD ;
PARISI, JT ;
BISNO, AL ;
SIMPSON, WA ;
BEACHEY, EH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1983, 18 (02) :258-269
[5]   IDENTIFICATION OF AN ANTIGENIC MARKER OF SLIME PRODUCTION FOR STAPHYLOCOCCUS-EPIDERMIDIS [J].
CHRISTENSEN, GD ;
BARKER, LP ;
MAWHINNEY, TP ;
BADDOUR, LM ;
SIMPSON, WA .
INFECTION AND IMMUNITY, 1990, 58 (09) :2906-2911
[6]   SUPPRESSION OF THROMBOXANE-A2 BUT NOT OF SYSTEMIC PROSTACYCLIN BY CONTROLLED-RELEASE ASPIRIN [J].
CLARKE, RJ ;
MAYO, G ;
PRICE, P ;
FITZGERALD, GA .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (16) :1137-1141
[7]   USEFULNESS OF A TEST FOR SLIME PRODUCTION AS A MARKER FOR CLINICALLY SIGNIFICANT INFECTIONS WITH COAGULASE-NEGATIVE STAPHYLOCOCCI [J].
DAVENPORT, DS ;
MASSANARI, RM ;
PFALLER, MA ;
BALE, MJ ;
STREED, SA ;
HIERHOLZER, WJ .
JOURNAL OF INFECTIOUS DISEASES, 1986, 153 (02) :332-339
[8]  
DIAZMITOMA F, 1987, J INFECT DIS, V156, P555
[9]   REDUCTION OF CAPSULAR POLYSACCHARIDE PRODUCTION IN KLEBSIELLA-PNEUMONIAE BY SODIUM-SALICYLATE [J].
DOMENICO, P ;
SCHWARTZ, S ;
CUNHA, BA .
INFECTION AND IMMUNITY, 1989, 57 (12) :3778-3782
[10]   STAPHYLOCOCCUS-EPIDERMIDIS EXTRACTED SLIME INHIBITS THE ANTIMICROBIAL ACTION OF GLYCOPEPTIDE ANTIBIOTICS [J].
FARBER, BF ;
KAPLAN, MH ;
CLOGSTON, AG .
JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (01) :37-40