DIFFERENTIAL SENSITIVITY TO DEXAMETHASONE INFLUENCE ON MORPHINE ANTINOCICEPTION IN 2 DIFFERENT STRAINS OF MICE - DBA/2J AND C57BL/6

被引：5

作者：

CAPASSO, A ^{[1
]}

DIGIANNUARIO, A ^{[1
]}

LOIZZO, A ^{[1
]}

PIERETTI, S ^{[1
]}

SORRENTINO, L ^{[1
]}

机构：

[1] IST SUPER SANITA, I-00161 ROME, ITALY

来源：

LIFE SCIENCES | 1993年 / 52卷 / 09期

关键词：

D O I：

10.1016/0024-3205(93)90082-E

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The influence of dexamethasone on morphine antinociception in two different strains of mice (DBA/2J and C57BL/6) was studied by using the hot plate test. Intracerebroventricular (i.c.v.) injection of dexamethasone induced a significant increase of nociceptive response in DBA/2J but not in C57BL/6 mice. Intraperitoneal (i.p.) injection of dexamethasone did not modify nociceptive response both in DBA/2J and C57BL/6 mice. Both i.c.v. and i.p. injection of dexamethasone did not modify morphine antinociception in DBA/2J mice whereas a significant reduction of morphine antinociception was observed in C57BL/6 mice after i.p. injection of dexamethasone. These results suggest that the use of different genetic strains may provide an useful approach for studying dexamethasone-morphine antinociception interaction.

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页码：835 / 844

页数：10

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