EVIDENCE FOR DELTA-OPIOID RECEPTOR SUBTYPES REGULATING ADENYLYL-CYCLASE ACTIVITY IN RAT-BRAIN

被引：30

作者：

BUZAS, B ^{[1
]}

IZENWASSER, S ^{[1
]}

PORTOGHESE, PS ^{[1
]}

COX, BM ^{[1
]}

机构：

[1] UNIV MINNESOTA, DEPT MED CHEM, MINNEAPOLIS, MN 55455 USA

来源：

LIFE SCIENCES | 1994年 / 54卷 / 07期

关键词：

D O I：

10.1016/0024-3205(94)00412-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Opioid agonists selective for mu- or delta opioid receptors inhibit adenylyl cyclase in membranes from rat caudate-putamen and nucleus accumbens. The presence of subtypes of delta opioid receptors has been suggested. In both brain regions we have found that the inhibition of adenylyl cyclase by DPDPE was more readily antagonized by 7-benzylidenenaltrexone (BNTX), than by naltriben. in contrast, the inhibitory effects of deltorphin-II and DSLET were more readily antagonized by naltriben, than by BNTX. Neither naltriben nor BNTX significantly antagonized the effect of a mu selective agonist. These results suggest that inhibition of adenylyl cyclase in caudate-putamen and nucleus accumbens is regulated by two forms of delta-opioid receptor with ligand selectivities similar to those two forms proposed to mediate analgesic effect.

引用

页码：PL101 / PL106

页数：6

共 18 条

[1] BOWEN WD, 1987, J BIOL CHEM, V262, P13434
[2] SIMPLE AND SENSITIVE SATURATION ASSAY METHOD FOR MEASUREMENT OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE
BROWN, BL
ALBANO, JDM
EKINS, RP
SGHERZI, AM
TAMPION, W
[J]. BIOCHEMICAL JOURNAL, 1971, 121 (03) : 561 - +
[3] SYNTHESIS AND BINDING CHARACTERISTICS OF THE HIGHLY DELTA-SPECIFIC NEW TRITIATED OPIOID PEPTIDE, [H-3] DELTORPHIN-II
BUZAS, B
TOTH, G
CAVAGNERO, S
HRUBY, VJ
BORSODI, A
[J]. LIFE SCIENCES, 1992, 50 (14) : PL75 - PL78
[4] DELTORPHINS - A FAMILY OF NATURALLY-OCCURRING PEPTIDES WITH HIGH-AFFINITY AND SELECTIVITY FOR DELTA-OPIOID BINDING-SITES
ERSPAMER, V
MELCHIORRI, P
FALCONIERIERSPAMER, G
NEGRI, L
CORSI, R
SEVERINI, C
BARRA, D
SIMMACO, M
KREIL, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) : 5188 - 5192
[5] CLONING OF A DELTA OPIOID RECEPTOR BY FUNCTIONAL EXPRESSION
EVANS, CJ
KEITH, DE
MORRISON, H
MAGENDZO, K
EDWARDS, RH
[J]. SCIENCE, 1992, 258 (5090) : 1952 - 1955
[6] PRELIMINARY LIGAND-BINDING DATA FOR SUBTYPES OF THE DELTA OPIOID RECEPTOR IN RAT-BRAIN MEMBRANES
HENG, X
QING, N
JACOBSON, AE
RICE, KC
ROTHMAN, RB
[J]. LIFE SCIENCES, 1991, 49 (18) : PL141 - PL146
[7] IZENWASSER S, IN PRESS J PHARM EXP
[8] JIANG Q, 1991, J PHARMACOL EXP THER, V257, P1069
[9] THE DELTA-OPIOID RECEPTOR - ISOLATION OF A CDNA BY EXPRESSION CLONING AND PHARMACOLOGICAL CHARACTERIZATION
KIEFFER, BL
BEFORT, K
GAVERIAUXRUFF, C
HIRTH, CG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) : 12048 - 12052
[10] MATTIA A, 1991, J PHARMACOL EXP THER, V258, P583

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