HIGH NITRIC-OXIDE PRODUCTION IN HUMAN PARANASAL SINUSES

被引：509

作者：

LUNDBERG, JON

FARKASSZALLASI, T

WEITZBERG, E

RINDER, J

LIDHOLM, J

ANGGARD, A

HOKFELT, T

LUNDBERG, JM

ALVING, K

机构：

[1] KAROLINSKA INST, DEPT NEUROSCI, S-17177 STOCKHOLM, SWEDEN

[2] KAROLINSKA HOSP, DEPT OTORHINOLARYNGOL, DEPT ANESTHESIOL & INTENS CARE, S-17176 STOCKHOLM, SWEDEN

[3] PHARMACIA DIAGNOST AB, S-75182 UPPSALA, SWEDEN

来源：

NATURE MEDICINE | 1995年 / 1卷 / 04期

关键词：

D O I：

10.1038/nm0495-370

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) is present in air derived from the nasal airways. However, the precise origin and physiological role of airway-derived NO ale unknown. We report that NO in humans is produced by epithelial cells in the paranasal sinuses and is present in sinus air tn very high concentrations, close to the highest permissible atmospheric pollution levels. In immunohistochemical and mRNA in situ hybridization studies we show that an NO synthase most closely resembling the inducible isoform is constitutively expressed apically in sinus epithelium. In contrast, only weak NO synthase activity was found in the epithelium of the nasal cavity. Our findings, together with the well-known bacteriostatic effects of NO, suggest a role for NO in the maintenance of sterility in the human paranasal sinuses.

引用

页码：370 / 373

页数：4

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