REACTIVITY OF THE MUTAGEN 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) WITH CHLORINE

被引：5

作者：

LANGVIK, VA

HOLMBOM, B

TIKKANEN, L

机构：

[1] ABO AKAD UNIV,DEPT FOREST PROD CHEM,SF-20500 TURKU,FINLAND

[2] ABO AKAD UNIV,DEPT ORGAN CHEM,SF-20500 TURKU,FINLAND

[3] TECHN RES CTR FINLAND,FOOD RES LAB,SF-02150 ESPOO,FINLAND

来源：

CHEMOSPHERE | 1991年 / 23卷 / 07期

关键词：

D O I：

10.1016/0045-6535(91)90092-R

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The mutagen MX, 2-chloro-3-(dichloromethyl)-4-oxo-butenoic acid, reacted quickly with chlorine at pH 7.2 in water but reacted slowly at pH 3 when present in the furanone form, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. The Ames-mutagenicity (TA 100, - S9) was reduced in direct proportion to the decrease in the MX amount. Thus the reaction products formed were much less mutagenic or not mutagenic at all. The dicarboxylic acids, Z- and E-2-chloro-3-(dichloromethyl)-butendioic acids, being potential oxidation products derived from MX, were determined but they may be regarded as minor reaction products.

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页码：873 / 880

页数：8

相关论文

共 18 条

[1] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].

AMES, BN ;

MCCANN, J ;

YAMASAKI, E .

MUTATION RESEARCH, 1975, 31 (06) :347-363

[2]

ANDER P, 1977, SVEN PAPPERSTIDN, V80, P454

[3] MUTAGENIC ACTIVITY AND PRESENCE OF THE STRONG MUTAGEN 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2-(5H)-FURANONE (MX) IN CHLORINATED RAW AND DRINKING WATERS IN THE NETHERLANDS [J].

BACKLUND, P ;

WONDERGEM, E ;

VOOGD, K ;

DEJONG, A .

SCIENCE OF THE TOTAL ENVIRONMENT, 1989, 84 :273-282

[4]

BACKLUND P, 1990, ORGANIC MICROPOLLUTA, P478

[5] DETERMINATION OF THE STRONG MUTAGEN 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE IN CHLORINATED DRINKING AND HUMIC WATERS [J].

HEMMING, J ;

HOLMBOM, B ;

REUNANEN, M ;

KRONBERG, L .

CHEMOSPHERE, 1986, 15 (05) :549-556

[6]

HOLMBOM B, 1989, CHEMOSPHERE, V18, P2237

[7]

HOLMBOM BR, 1981, TAPPI, V64, P172

[8] AMES MUTAGENICITY AND CONCENTRATION OF THE STRONG MUTAGEN 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE AND OF ITS GEOMETRIC ISOMER E-2-CHLORO-3-(DICHLOROMETHYL)-4-OXO-BUTENOIC ACID IN CHLORINE-TREATED TAP WATERS [J].

KRONBERG, L ;

VARTIAINEN, T .

MUTATION RESEARCH, 1988, 206 (02) :177-182

[9] IDENTIFICATION OF OXIDIZED AND REDUCED FORMS OF THE STRONG BACTERIAL MUTAGEN (Z)-2-CHLORO-3-(DICHLOROMETHYL)-4-OXOBUTENOIC ACID (MX) IN EXTRACTS OF CHLORINE-TREATED WATER [J].

KRONBERG, L ;

CHRISTMAN, RF ;

SINGH, R ;

BALL, LM .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1991, 25 (01) :99-104

[10] IDENTIFICATION AND QUANTIFICATION OF THE AMES MUTAGENIC COMPOUND 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE AND OF ITS GEOMETRIC ISOMER (E)-2-CHLORO-3-(DICHLOROMETHYL)-4-OXOBUTENOIC ACID IN CHLORINE-TREATED HUMIC WATER AND DRINKING-WATER EXTRACTS [J].

KRONBERG, L ;

HOLMBOM, B ;

REUNANEN, M ;

TIKKANEN, L .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1988, 22 (09) :1097-1103