MICROBIAL MODELS OF MAMMALIAN METABOLISM - FUNGAL METABOLISM OF THE DITERPENE SCLAREOL BY CUNNINGHAMELLA SPECIES

被引：31

作者：

KOUZI, SA

MCCHESNEY, JD

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 02期

关键词：

D O I：

10.1021/np50074a021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Microbial metabolism of the diterpene sclareol {1} was studied. Screening studies have shown a number of microorganisms capable of metabolizing sclareol. Preparative scale fermentation with Cunninghamella species NRRL 5695 has resulted in the production of two fungal metabolites that have been characterized as 3-beta-hydroxysclareol {2} and 18-hydroxysclareol {3} with the use of 2D nmr techniques. The yield of the two metabolites was improved by utilizing resting-cell suspensions of Cunninghamella species NRRL 5695.

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页码：483 / 490

页数：8

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