PILOT SCALE PRODUCTION OF PYROGEN-FREE HUMAN HEMOGLOBIN FOR RESEARCH

被引：15

作者：

CHAPMAN, KW

SNELL, SM

JESSE, RG

MORANO, JK

EVERSE, J

WINSLOW, RM

机构：

[1] Division of Blood Research, Letterman Army Institute of Research, Presidio of San Francisco

来源：

BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY | 1992年 / 20卷 / 2-4期

关键词：

D O I：

10.3109/10731199209119661

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A pilot scale production facility for the preparation of 20 to 30 liters of stroma-free hemoglobin is described. The system is capable of producing pyrogen-free solutions for research purposes. It is not certified for production of parenteral solutions for human use, but the plan could be implemented to meet standards for such materials. Products of the facility should be of adequate quality to address most of the toxicity and efficacy issues facing further development of hemoglobin-based red cell substitutes.

引用

页码：415 / 421

页数：7

共 10 条

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