PHOSPHOLIPASE-A2 INHIBITION BY MANOALIDE - DEVELOPMENT OF SIMPLE ANALOGS AND NECESSARY FUNCTIONAL-GROUPS FOR INHIBITION

被引：14

作者：

KATSUMURA, S

HAN, Q

KADONO, H

FUJIWARA, S

ISOE, S

FUJII, S

NISHIMURA, H

IKEDA, K

机构：

[1] OSAKA CITY UNIV,FAC SCI,OSAKA 558,JAPAN

[2] OSAKA UNIV PHARMACEUT SCI,DEPT BIOCHEM,MATSUBARA,OSAKA 580,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80226-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Manoalide analogue 1a inhibited bovine pancreatic phospholipase A2 to the same extent as seco-manoalide. Two aldehyde groups in a manoalide molecule are indispensable to the enzyme inhibition.

引用

页码：1263 / 1266

页数：4

共 17 条

[1]

Dennis EA., 1983, ENZYMES, P307

[2] 3 NEW SESTERTERPENOID ANTIBIOTICS FROM THE MARINE SPONGE LUFFARIELLA-VARIABILIS (POLEJAFF) [J].

DESILVA, ED ;

SCHEUER, PJ .

TETRAHEDRON LETTERS, 1981, 22 (33) :3147-3150

[3] ACTIVE-SITE AND CATALYTIC MECHANISM OF PHOSPHOLIPASE-A2 [J].

DIJKSTRA, BW ;

DRENTH, J ;

KALK, KH .

NATURE, 1981, 289 (5798) :604-606

[4] INACTIVATION OF BEE VENOM PHOSPHOLIPASE-A2 BY MANOALIDE - A MODEL BASED ON THE REACTIVITY OF MANOALIDE WITH AMINO-ACIDS AND PEPTIDE SEQUENCES [J].

GLASER, KB ;

JACOBS, RS .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (13) :2079-2086

[5] INACTIVATION OF PHOSPHOLIPASE-A2 BY MANOALIDE - LOCALIZATION OF THE MANOALIDE BINDING-SITE ON BEE VENOM PHOSPHOLIPASE-A2 [J].

GLASER, KB ;

VEDVICK, TS ;

JACOBS, RS .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (19) :3639-3646

[6]

GLASER KB, 1989, MOL PHARMACOL, V36, P782

[7] SOME PHARMACOLOGICAL OBSERVATIONS ON MARINE NATURAL-PRODUCTS [J].

JACOBS, RS ;

CULVER, P ;

LANGDON, R ;

OBRIEN, T ;

WHITE, S .

TETRAHEDRON, 1985, 41 (06) :981-984

[8] TOTAL SYNTHESIS OF E-NEOMANOALIDE VIA PD(O) CATALYZED COUPLING OF ALLYLHALIDE AND ALPHA-STANNYLFURAN FOLLOWED BY CHEMOSELECTIVE OXYGENATION OF ALPHA-SILYLFURAN [J].

KATSUMURA, S ;

FUJIWARA, S ;

ISOE, S .

TETRAHEDRON LETTERS, 1987, 28 (11) :1191-1194

[9] HIGHLY EFFICIENT TOTAL SYNTHESIS OF MANOALIDE AND SECO-MANOALIDE VIA PD(0) CATALYZED COUPLING OF ALLYLHALIDE WITH CO AND 2-SILYL-4-STANNYLFURAN [J].

KATSUMURA, S ;

FUJIWARA, S ;

ISOE, S .

TETRAHEDRON LETTERS, 1988, 29 (10) :1173-1176

[10]

KATSUMURA S, 1985, TETRAHEDRON LETT, V26, P527

← 1 2 →