EFFECT OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITION ON PLASMA BRAIN NATRIURETIC PEPTIDE LEVELS IN PATIENTS WITH HEART-FAILURE

被引:12
作者
LANG, CC
MOTWANI, JG
RAHMAN, AR
COUTIE, WJ
STRUTHERS, AD
机构
[1] Department of Clinical Pharmacology, Ninewells Hospital/Medical School
关键词
ANGIOTENSIN-CONVERTING ENZYME INHIBITION; ATRIAL NATRIURETIC PEPTIDE; BRAIN NATRIURETIC PEPTIDE; CONGESTIVE HEART FAILURE;
D O I
10.1042/cs0830143
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1. The aim of this study was to examine the effect of captopril, an angiotensin-converting enzyme inhibitor, on plasma levels of human brain natriuretic peptide-like immunoreactivity (hBNP-li) in patients with congestive heart failure. 2. Six male patients (aged 52-74 years) with mild to moderate congestive heart failure were studied on two occasions in the semi-recumbent position. After a 30 min rest, patients were randomized to receive oral tablets of either captopril (6.25 mg followed by 25 mg 2h later) or placebo in a single-blind manner. Plasma hBNP-li, atrial natriuretic peptide-like immunoreactivity (ANP-li) and angiotensin II-like immunoreactivity (ANG II-li) levels and blood pressure were measured. 3. Baseline plasma hBNP-li and ANP-li levels in these patients with mild to moderate congestive heart failure were 13.5+/-3.2 pmol/l and 50.9+/-11.8 pmol/l, respectively. In 11 healthy male subjects aged 20-23 years, the peripheral plasma hBNP-li and ANP-li levels were 1.3+/-0.2 pmol/l and 5.6+/-1.7 pmol/l, respectively. In all patients, captopril decreased the plasma ANG II-li level (from 24.3+/-8.1 to 6.6+/-3.2 pmol/l, P<0.05) and mean arterial blood pressure (from 92+/-3 to 80+/-3 mmHg, P<0.05). Compared with placebo, captopril treatment was associated with significant reductions in plasma hBNP-li (from 14.3+/-3.0 to 12.8+/-2.1 pmol/l, P<0.05) and in plasma ANP-li (from 53.9+/-1.11 to 36.8+/-7.6 pmol/l, P<0.05) levels. 4. Our results show that in patients with heart failure, acute inhibition of angiotensin-converting enzyme with captopril results in falls in both plasma hBNP-li (10% fall) and ANP-li (32% fall) levels. Our results do not support a major role for angiotensin-converting enzyme in the metabolism of human brain natriuretic peptide in heart failure, although a minor role cannot be excluded since the fall in the plasma ANP-li level was greater than the fall in the plasma hBNP-li level. However, the fall in the plasma hBNP-li level is most probably related to the changes induced in intra-cardiac volume/pressure by the angiotensin-converting enzyme inhibitor.
引用
收藏
页码:143 / 147
页数:5
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