A NETWORK MODEL OF DEVELOPMENTAL GENE HIERARCHY

被引:23
作者
BURSTEIN, Z
机构
[1] Institute for Philosophy of Science, Tel-Aviv University
关键词
D O I
10.1006/jtbi.1995.0075
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A network model of development governing the whole temporal and spatial hierarchy of early embryogenesis and pattern formation in Drosophila is introduced. The network is related to a neural network model, with its units being developmental genes mostly connected by the genes' DNA-binding products. The developmental network's agreement with predictions regarding architecture and function of the neural network provides adequate grounds for an analogy between the two. The model is tested through computer simulations-predictions compare favorably with experimental observations. The model not only incorporates a program of control at gene level, but also makes a direct connection with current molecular studies throughout the whole hierarchy of the early embryogenesis of Drosophila.
引用
收藏
页码:1 / 11
页数:11
相关论文
共 61 条
[1]  
AKAM M, 1987, DEVELOPMENT, V101, P1
[2]  
Amit D. J., 1989, MODELING BRAIN FUNCT
[3]   NETWORK OF INTERACTIONS AMONG PAIR-RULE GENES REGULATING PAIRED EXPRESSION DURING PRIMORDIAL SEGMENTATION OF DROSOPHILA [J].
BAUMGARTNER, S ;
NOLL, M .
MECHANISMS OF DEVELOPMENT, 1990, 33 (01) :1-18
[4]   AN AUTOREGULATORY ENHANCER ELEMENT OF THE DROSOPHILA HOMEOTIC GENE DEFORMED [J].
BERGSON, C ;
MCGINNIS, W .
EMBO JOURNAL, 1990, 9 (13) :4287-4297
[5]   THE ROLE OF LOCALIZATION OF BICOID RNA IN ORGANIZING THE ANTERIOR PATTERN OF THE DROSOPHILA EMBRYO [J].
BERLETH, T ;
BURRI, M ;
THOMA, G ;
BOPP, D ;
RICHSTEIN, S ;
FRIGERIO, G ;
NOLL, M ;
NUSSLEINVOLHARD, C .
EMBO JOURNAL, 1988, 7 (06) :1749-1756
[6]   A NEW CONCEPT OF DEVELOPMENTAL AND EVOLUTIONARY ADAPTATION [J].
BURSTEIN, Z .
JOURNAL OF SOCIAL AND BIOLOGICAL STRUCTURES, 1991, 14 (01) :15-33
[7]   THE ORIGIN OF MUTANTS [J].
CAIRNS, J ;
OVERBAUGH, J ;
MILLER, S .
NATURE, 1988, 335 (6186) :142-145
[8]  
CHOUINARD S, 1991, DEVELOPMENT, V113, P1267
[9]   Modeling and experiment in developmental biology [J].
Cox, Edward C. .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1992, 2 (04) :647-650
[10]   COMPARTMENTS AND POLYCLONES IN INSECT DEVELOPMENT [J].
CRICK, FHC ;
LAWRENCE, PA .
SCIENCE, 1975, 189 (4200) :340-347