MODIFIED CRUSH-AVULSION ANASTOMOSIS MODEL ON THE RAT FEMORAL VEIN

被引：8

作者：

FU, KD ^{[1
]}

IZQUIERDO, R ^{[1
]}

HUBBARD, T ^{[1
]}

FAREED, J ^{[1
]}

机构：

[1] LOYOLA UNIV,STRITCH SCH MED,DIV PLAST SURG,MAYWOOD,IL 60153

来源：

MICROSURGERY | 1995年 / 16卷 / 08期

关键词：

D O I：

10.1002/micr.1920160806

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A crush-avulsion anastomosis model was established on the rat femoral vein, Saline or heparin was used as a luminal topical agent and was allowed to contact the damaged endothelium for 10 min, Patency and coagulation parameters were investigated for 1 week, The heparin treated group had a patency rate of 93% at 1 hr vs. 13% for the saline treated group (P < 0.001). At 7 days, the heparin treated group had an 87% patency vs, 7% for the saline-treated group (P < 0.001). Scanning electron micrography (SEM) provided evidence of the deposition of the components of early thrombosis in the crushed venous wall, In contrast, the SEM of the heparin treated group shows a paucity of any evidence of thrombus. These results indicate that the rat vein crush-avulsion model is a reliable and reproducible thrombosis model with low patency. The methods used with the topical agent may improve the patency rate in crush avulsion injuries. (C) 1995 Wiley-Liss, Inc.

引用

页码：536 / 541

页数：6

共 17 条

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