BIOLOGICAL-ACTIVITY OF SYNTHETIC HEPTAACYL LIPID-A REPRESENTING A COMPONENT OF SALMONELLA MINNESOTA R595 LIPID-A

被引：69

作者：

GALANOS, C

LUDERITZ, O

FREUDENBERG, M

BRADE, L

SCHADE, U

RIETSCHEL, ET

KUSUMOTO, S

SHIBA, T

机构：

[1] MAX PLANCK INST IMMUNBIOL, STUBEWEG 51, D-7800 FREIBURG, GERMANY

[2] OSAKA UNIV, FAC SCI, OSAKA, JAPAN

[3] FORSCHUNGSINST BORSTEL, D-2061 BORSTEL, GERMANY

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1986年 / 160卷 / 01期

关键词：

D O I：

10.1111/j.1432-1033.1986.tb09939.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A synthetic lipid A (preparation 516), containing seven acyl groups and representing one component of natural free lipid A of Salmonella minnesota R595, has been investigated for biological activity in a number of endotoxin test systems. It was found that the synthetic preparation was, in typical in vivo endotoxin tests (lethality, pyrogenicity, Shwartzman reactivity) as well as in its antigenicity and macrophage activation capacity, significantly less active than natural Salmonella lipid A. However, in other in vitro assay systems (B-cell mitogenicity, complement activation, Limulus amoebocyte lyzate gelation) it expressed similar activity as Salmonella lipid A.

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页码：55 / 59

页数：5

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