THE MECHANISM OF THE HISTAMINE-INDUCED DESENSITIZATION OF GUINEA-PIG ILEUM

被引：15

作者：

BIELKIEWICZ, B ^{[1
]}

COOK, DA ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT PHARMACOL, EDMONTON T6G 2H7, ALBERTA, CANADA

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1984年 / 15卷 / 01期

关键词：

D O I：

10.1016/0306-3623(84)90080-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Histamine and the selective H1 receptor agonist 2-pyridylethylamine show cross-desensitization when tested in guinea-pig ileum. The H1 receptor blocking agent produces a smaller parallel shift in desensitized tissues when compared with non-desensitized controls. Evidently, desensitization in this system occurs at the receptor level and is reflected by a decreased sensitivity to both agonists and antagonists.

引用

页码：51 / 54

页数：4

共 13 条

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