MORNING OR NIGHTTIME MELATONIN IS INEFFECTIVE IN SEASONAL AFFECTIVE-DISORDER

被引：46

作者：

WIRZJUSTICE, A ^{[1
]}

GRAW, P ^{[1
]}

KRAUCHI, K ^{[1
]}

GISIN, B ^{[1
]}

ARENDT, J ^{[1
]}

ALDHOUS, M ^{[1
]}

POLDINGER, W ^{[1
]}

机构：

[1] UNIV SURREY, DEPT CLIN BIOCHEM, GUILDFORD GU2 5XH, SURREY, ENGLAND

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 1990年 / 24卷 / 02期

关键词：

D O I：

10.1016/0022-3956(90)90053-S

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Melatonin, at the same doses used to treat circadian-rhythm related sleep disturbances, had no effect on the depressive symptoms in seasonal affective disorder (SAD) patients, whether given early (7 a.m.) or late (11 p.m.) for a week. Slight improvements in sleep were seen with night-time administration. The circadian rhythmicity of urinary 6-sulphatoxymelatonin was not modified in any way. Melatonin at this dosage (5 mg/day) or at these two times is therefore not a potential alternative treatment for SAD; light remains the therapy of choice. © 1990.

引用

页码：129 / 137

页数：9

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