A PHASE-I STUDY OF THE COMBINED HYPOXIC CELL RADIOSENSITIZERS, RO 03-8799 AND SR 2508 - A PRELIMINARY-REPORT OF SINGLE-DOSE TOXICITY, PHARMACOKINETICS AND TUMOR CONCENTRATIONS

被引：19

作者：

NEWMAN, HFV ^{[1
]}

BLEEHEN, NM ^{[1
]}

WORKMAN, P ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT CLIN ONCOL & RADIOTHERAPEUT,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

BRITISH JOURNAL OF RADIOLOGY | 1986年 / 59卷 / 700期

关键词：

D O I：

10.1259/0007-1285-59-700-423

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

引用

页码：423 / 425

页数：3

共 11 条

[1] BROWN JM, 1981, INT J RADIAT ONCOL, V7, P695
[2] PARTITION-COEFFICIENT AS A GUIDE TO THE DEVELOPMENT OF RADIOSENSITIZERS WHICH ARE LESS TOXIC THAN MISONIDAZOLE
BROWN, JM
WORKMAN, P
[J]. RADIATION RESEARCH, 1980, 82 (01) : 171 - 190
[3] INITIAL REPORT OF THE PHASE-I TRIAL OF THE HYPOXIC CELL RADIOSENSITIZER SR-2508
COLEMAN, CN
URTASUN, RC
WASSERMAN, TH
HANCOCK, S
HARRIS, JW
HALSEY, J
HIRST, VK
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09): : 1749 - 1753
[4] CELLULAR UPTAKE OF MISONIDAZOLE AND ANALOGS WITH ACIDIC OR BASIC FUNCTIONS
DENNIS, MF
STRATFORD, MRL
WARDMAN, P
WATTS, ME
[J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1985, 47 (06) : 629 - 643
[5] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF THE NEW HYPOXIC CELL RADIOSENSITIZER, RO 03-8799, IN BIOLOGICAL SAMPLES
MALCOLM, SL
LEE, A
GROVES, JK
[J]. JOURNAL OF CHROMATOGRAPHY, 1983, 273 (02): : 327 - 333
[6] A PHASE-I STUDY OF THE HYPOXIC CELL RADIOSENSITIZER RO-03-8799
ROBERTS, JT
BLEEHEN, NM
WORKMAN, P
WALTON, MI
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09): : 1755 - 1758
[7] A CLINICAL PHASE-1 TOXICITY STUDY OF RO-03-8799 - PLASMA, URINE, TUMOR AND NORMAL BRAIN PHARMACOKINETICS
ROBERTS, JT
BLEEHEN, NM
WALTON, MI
WORKMAN, P
[J]. BRITISH JOURNAL OF RADIOLOGY, 1986, 59 (698) : 107 - 116
[8] THE CLINICAL-TESTING OF RO 03-8799 PHARMACOKINETICS, TOXICOLOGY, TISSUE AND TUMOR CONCENTRATIONS
SAUNDERS, MI
ANDERSON, PJ
BENNETT, MH
DISCHE, S
MINCHINTON, A
STRATFORD, MRL
TOTHILL, M
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09): : 1759 - 1763
[9] Smithen C., 1980, RAD SENSITIZERS THEI, P22
[10] INVIVO TESTING OF A 2-NITROIMIDAZOLE RADIOSENSITIZER (RO-03-8799) USING REPEATED ADMINISTRATION
WILLIAMS, MV
DENEKAMP, J
MINCHINTON, AI
STRATFORD, MRL
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4): : 477 - 481

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