GAMMA-HYDROXYBUTYRATE HYPERPOLARIZES HIPPOCAMPAL-NEURONS BY ACTIVATING GABA(B)RECEPTORS

被引：90

作者：

XIE, XM

SMART, TG

机构：

[1] Department of Pharmacology, The School of Pharmacy, London

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 212卷 / 2-3期

关键词：

GAMMA-HYDROXYBUTYRATE; GABA (GAMMA-AMINOBUTYRIC ACID); GABA(B)RECEPTORS; CGP35348; HIPPOCAMPUS; ZN2+;

D O I：

10.1016/0014-2999(92)90347-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gamma-Hydroxybutyrate, a naturally occurring substance present in the mammalian central nervous system caused a dose-dependent (0.25-10 mM) hyperpolarization and small membrane conductance increase when applied to hippocampal CA1 pyramidal neurones in vitro. This action was reversibly inhibited by the GABA(B) antagonist, CGP 35348 (20-100-mu-M) and divalent cations, Zn2+ and Ba2+, but not by the GABA(A) antagonist bicuculline (50-mu-M). These results suggest that GABA(B) receptors may mediate the actions of gamma-hydroxybutyrate.

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页码：291 / 294

页数：4

相关论文

共 10 条

[1]

BERNASCONI RJ, IN PRESS J NEURAL TR

[2] A PHYSIOLOGICAL-ROLE FOR GABAB RECEPTORS IN THE CENTRAL NERVOUS-SYSTEM [J].

DUTAR, P ;

NICOLL, RA .

NATURE, 1988, 332 (6160) :156-158

[3] GABAB-RECEPTOR-ACTIVATED K+ CURRENT IN VOLTAGE-CLAMPED CA3 PYRAMIDAL CELLS IN HIPPOCAMPAL CULTURES [J].

GAHWILER, BH ;

BROWN, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (05) :1558-1562

[4] THE EFFECTS OF GAMMA-HYDROXYBUTYRATE ON THE MEMBRANE-PROPERTIES OF GUINEA-PIG PARS COMPACTA NEURONS IN THE SUBSTANTIA NIGRA INVITRO [J].

HARRIS, NC ;

WEBB, C ;

GREENFIELD, SA .

NEUROSCIENCE, 1989, 31 (02) :363-370

[5] CGP 35348 - A CENTRALLY ACTIVE BLOCKER OF GABA-B RECEPTORS [J].

OLPE, HR ;

KARLSSON, G ;

POZZA, MF ;

BRUGGER, F ;

STEINMANN, M ;

VANRIEZEN, H ;

FAGG, G ;

HALL, RG ;

FROESTL, W ;

BITTIGER, H .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (01) :27-38

[6] INHIBITION OF NIGRAL AND NEOCORTICAL CELLS BY GAMMA-HYDROXYBUTYRATE - MICROIONTOPHORETIC INVESTIGATION [J].

OLPE, HR ;

KOELLA, WP .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 53 (04) :359-364

[7] THE GAMMA-HYDROXYBUTYRATE MODEL OF ABSENCE SEIZURES - CORRELATION OF REGIONAL BRAIN LEVELS OF GAMMA-HYDROXYBUTYRIC ACID AND GAMMA-BUTYROLACTONE WITH SPIKE WAVE DISCHARGES [J].

SNEAD, OC .

NEUROPHARMACOLOGY, 1991, 30 (02) :161-167

[8] GAMMA-HYDROXYBUTYRATE STIMULATION OF THE FORMATION OF CYCLIC-GMP AND INOSITOL PHOSPHATES IN RAT HIPPOCAMPAL SLICES [J].

VAYER, P ;

MAITRE, M .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (05) :1382-1387

[9] GAMMA-HYDROXYBUTYRATE, A POSSIBLE NEUROTRANSMITTER [J].

VAYER, P ;

MANDEL, P ;

MAITRE, M .

LIFE SCIENCES, 1987, 41 (13) :1547-1557

[10] A PHYSIOLOGICAL-ROLE FOR ENDOGENOUS ZINC IN RAT HIPPOCAMPAL SYNAPTIC NEUROTRANSMISSION [J].

XIE, XM ;

SMART, TG .

NATURE, 1991, 349 (6309) :521-524