BENZOPHENANTHRIDINE ALKALOIDS ISOLATED FROM ESCHSCHOLTZIA-CALIFORNICA CELL-SUSPENSION CULTURES INTERACT WITH VASOPRESSIN(V1) RECEPTORS

被引：15

作者：

GRANGER, I

SERRADEILLEGAL, C

AUGEREAU, JM

GLEYE, J

机构：

[1] SANOFI RECH,BIOCHIM EXPLORATOIRE LAB,195 ROUTE ESPAGNE,F-31036 TOULOUSE,FRANCE

[2] FAC SCI PHARMACEUT TOULOUSE,PHARMACOGNOSIE LAB,F-31400 TOULOUSE,FRANCE

[3] SANOFI ELF BIO RECH,PHYTOTECHNOL LAB,F-31328 LABEGE,FRANCE

来源：

PLANTA MEDICA | 1992年 / 58卷 / 01期

关键词：

ESCHSCHOLTZIA-CALIFORNICA; PAPAVERACEAE; BENZOPHENANTHRIDINE ALKALOIDS; VASOPRESSIN V1-RECEPTORS;

D O I：

10.1055/s-2006-961385

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chelerythrine and sanguinarine, two benzophenanthridine alkaloids, have been isolated from a crude methanolic extract of Eschscholtzia californica cell suspension cultures by successive fractionations. These two molecules exhibited affinity for rat liver vasopressin V1 receptors and are competitive inhibitors of [H-3]-vasopressin binding within the micromolar range (K(i)). Chelerythrine and sanguinarine represent two of the first non-peptidic structures providing original chemical leads for the design of synthetic vasopressin compounds.

引用

页码：35 / 38

页数：4

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