BENZOPHENANTHRIDINE AND FUROQUINOLINE ACCUMULATION IN CELL-SUSPENSION CULTURES OF FAGARA ZANTHOXYLOIDES

被引:14
作者
COUILLEROT, E
CARON, C
COMOE, L
AUDRAN, JC
MOLINATTI, P
ZECHES, M
LEMENOLIVIER, L
JARDILLIER, JC
CHENIEUX, JC
机构
[1] UFR PHARM, PHARMACOGNOSIE LAB, CNRS, URA 492, F-51096 REIMS, FRANCE
[2] UNIV REIMS, UFR SCI, BIOL & PHYSIOL VEGETALES LAB, F-51062 REIMS, FRANCE
[3] UNIV REIMS, UFR PHARM, GIBSA, BIOCHIM LAB, F-51096 REIMS, FRANCE
[4] UNIV REIMS, INST JEAN GODINOT, F-51096 REIMS, FRANCE
[5] UNIV TOURS, FAC PHARM, BIOL CELLULAIRE & BIOCHIM VEGETALE LAB, F-37200 TOURS, FRANCE
关键词
FAGARA ZANTHOXYLOIDES; RUTACEAE; PLANT CELL CULTURE; ALKALOIDS; BENZOPHENANTHRIDINES; FUROQUINOLINES; LIGNAN; FAGARONINE; ANTILEUKEMIC PROPERTIES;
D O I
10.1016/0031-9422(94)85072-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
In vitro cell culture of Fagara zanthoxyloides is reported for the first time. The cell suspension cultures produced fagaronine, but the production of this metabolite was lost after several subcultures, whereas furoquinoline accumulation remained high and constant.
引用
收藏
页码:425 / 428
页数:4
相关论文
共 20 条
[1]
ALKALOIDS FROM MELICOPE-LERATII [J].
AHOND, A ;
PICOT, F ;
POTIER, P ;
POUPAT, C ;
SEVENET, T .
PHYTOCHEMISTRY, 1978, 17 (01) :166-167
[2]
CHEMISTRY OF ZANTHOXYLUM-RHOIFOLIUM - A NEW SECOFUROQUINOLINE ALKALOID [J].
ARRUDA, MSP ;
FERNANDES, JB ;
VIEIRA, PC ;
DA SILVA, MFGF ;
PIRANI, JR .
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 1992, 20 (02) :173-178
[3]
THE ANTILEUKEMIC ALKALOID FAGARONINE AND THE HUMAN K-562 LEUKEMIC-CELLS - EFFECTS ON GROWTH AND INDUCTION OF ERYTHROID-DIFFERENTIATION [J].
COMOE, L ;
JEANNESSON, P ;
TRENTESAUX, C ;
DESOIZE, B ;
JARDILLIER, JC .
LEUKEMIA RESEARCH, 1987, 11 (05) :445-451
[4]
EFFECT OF FAGARONINE ON CELL-CYCLE PROGRESSION OF HUMAN ERYTHROLEUKEMIA K562 CELLS [J].
COMOE, L ;
CARPENTIER, Y ;
DESOIZE, B ;
JARDILLIER, JC .
LEUKEMIA RESEARCH, 1988, 12 (08) :667-672
[5]
COMOE L, 1987, THESIS ETAT SC PHARM
[6]
EVDOKIMOVA NI, 1973, CHEM ABSTR 119189, V78
[7]
CHELERYTHRINE IS A POTENT AND SPECIFIC INHIBITOR OF PROTEIN-KINASE-C [J].
HERBERT, JM ;
AUGEREAU, JM ;
GLEYE, J ;
MAFFRAND, JP .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 172 (03) :993-999
[8]
STEREOCHEMICAL STUDIES ON THE BIOSYNTHESIS OF PROTOBERBERINE, PROTOPINE, AND BENZOPHENANTHRIDINE ALKALOIDS USING PAPAVERACEAE PLANT-CELL CULTURES [J].
IWASA, K ;
KAMIGAUCHI, M ;
TAKAO, N ;
CUSHMAN, M .
JOURNAL OF NATURAL PRODUCTS, 1993, 56 (12) :2053-2067
[9]
ENZYMOLOGY AND MOLECULAR-BIOLOGY OF ALKALOID BIOSYNTHESIS [J].
KUTCHAN, TM ;
DITTRICH, H ;
BRACHER, D ;
ZENK, MH .
TETRAHEDRON, 1991, 47 (31) :5945-5954
[10]
THE ANTILEUKEMIC ALKALOID FAGARONINE IS AN INHIBITOR OF DNA TOPOISOMERASE-I AND TOPOISOMERASE-II [J].
LARSEN, AK ;
GRONDARD, L ;
COUPRIE, J ;
DESOIZE, B ;
COMOE, L ;
JARDILLIER, JC ;
RIOU, JF .
BIOCHEMICAL PHARMACOLOGY, 1993, 46 (08) :1403-1412