DIFFERING ACTIONS OF BACLOFEN AND 3-AMINO-PROPYLPHOSPHINIC ACID IN RAT NEOCORTICAL SLICES

被引:25
作者
ONG, J
KERR, DIB
JOHNSTON, GAR
HALL, RG
机构
[1] UNIV SYDNEY,DEPT PHARMACOL,SYDNEY,NSW 2006,AUSTRALIA
[2] CIBA GEIGY PLC,CENT RES,MANCHESTER,ENGLAND
关键词
2-Hydroxy-saclofen; 3-Amino-propylphosphinic acid; Baclofen; Magnesium-free medium; Rat neocortex; γ-Aminobutyric acid-B receptor;
D O I
10.1016/0304-3940(90)90557-P
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rat neocortical slices maintained in Mg2+-free Krebs medium developed spontaneous paroxysmal discharges which were attenuated or suppressed by the γ-aminobutyric acid-B (GABAB) receptor agonist baclofen, occasionally accompanied by a slight hyperpolarisation, and antagonised by the specific GABAB-receptor antagonist, 2-OH-saclofen. Over the same dose range, the GABA-analogue 3-amino-propylphosphinic acid (3-APA) caused a marked, prompt hyperpolarisation with little or no effect on the frequency of the discharges, although their amplitude was attenuated. In the presence of 2-OH-saclofen, 3-APA still induced a hyperpolarisation but the amplitude of the discharges was no longer affected. This marked difference in action between baclofen and 3-APA in the rat neocortical slices suggests there may be a heterogeneity of GABAB-receptors. © 1990.
引用
收藏
页码:169 / 173
页数:5
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