GRANULOCYTE-COLONY-STIMULATING FACTOR THERAPY IN DRUG-INDUCED AGRANULOCYTOSIS

被引：13

作者：

MANI, S

BARRY, M

CONCATO, J

机构：

[1] VET AFFAIRS MED CTR,MED SERV 111,950 CAMPBELL AVE,W HAVEN,CT 06516

[2] YALE UNIV,SCH MED,DEPT INTERNAL MED,NEW HAVEN,CT 06510

来源：

ARCHIVES OF INTERNAL MEDICINE | 1993年 / 153卷 / 21期

关键词：

D O I：

10.1001/archinte.153.21.2500

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Drug-induced agranulocytosis in the outpatient setting is a rare but potentially fatal adverse effect of many classes of medications. Five patients with this disorder presented to Yale-New Haven (Conn) Hospital during 1990 through 1992. Three patients treated with granulocyte-colony stimulating factor and two patients treated with routine care were studied for relevant clinical outcomes. Treatment with granulocyte-colony stimulating factor was associated with a shorter duration of neutropenia and a decreased length of hospital stay, consistent with recent case reports. Despite the high cost of the drug, treatment with granulocyte-colony stimulating factor was found to be cost-effective for patients with uncomplicated drug

引用

页码：2500 / 2501

页数：2

共 11 条

[1]

ARNEBORN P, 1979, ACTA MED SCAND, V206, P19203

[2]

BOTTIGER LE, 1979, ACTA MED SCAND, V205, P457

[3] GM-CSF THERAPY FOR DRUG-INDUCED AGRANULOCYTOSIS [J].