ISOLATION OF HIGH-MOLECULAR-WEIGHT C-TYPE NATRIURETIC PEPTIDE FROM THE HEART OF A CARTILAGINOUS FISH (EUROPEAN DOGFISH, SCYLIORHINUS-CANICULA)

被引：67

作者：

SUZUKI, R

TAKAHASHI, A

HAZON, N

TAKEI, Y

机构：

[1] KITASATO UNIV,SCH MED,DEPT PHYSIOL,SAGAMIHARA,KANAGAWA 228,JAPAN

[2] KITASATO UNIV,SCH MED,DEPT MOLEC BIOL,SAGAMIHARA,KANAGAWA 228,JAPAN

[3] SUMITOMO MET IND LTD,DEPT BIOTECHNOL & MED BUSINESS,BIOTECHNOL SECT,SAGAMIHARA,KANAGAWA 229,JAPAN

[4] UNIV ST ANDREWS,DEPT BIOL & PRECLIN MED,GATTY MARINE LAB,ST ANDREWS KY16 8LB,SCOTLAND

[5] KITASATO UNIV,SCH MED,DEPT MOLEC BIOL,SAGAMIHARA,KANAGAWA 228,JAPAN

来源：

FEBS LETTERS | 1991年 / 282卷 / 02期

关键词：

NATRIURETIC PEPTIDE; CARTILAGINOUS FISH; AMINO ACID SEQUENCE; SEQUENCE HOMOLOGY; HEART; SCYLIORHINUS-CANICULA;

D O I：

10.1016/0014-5793(91)80505-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A high-molecular-weight form of C-type natriuretic peptide (CNP) was isolated from both cardiac atria and ventricles of European dogfish, Scyliorhinus canicula, and its primary structure was determined. The peptide consists of 115 amino acid residues, in which the C-terminal 22 residues show high homology to CNPs identified to date. This is the first direct evidence for the presence of natriuretic peptide in the cartilaginous fish, and for the presence of CNP in an organ other than the brain.

引用

页码：321 / 325

页数：5

共 10 条

[1]

HIRS CHW, 1967, METHOD ENZYMOL, V11, P199

[2] CLONING AND SEQUENCE-ANALYSIS OF A CDNA-ENCODING A PRECURSOR FOR RAT C-TYPE NATRIURETIC PEPTIDE (CNP) [J].