GENE COMPLEMENTING XERODERMA-PIGMENTOSUM GROUP A CELLS MAPS TO DISTAL HUMAN CHROMOSOME-9Q

被引：13

作者：

HENNING, KA

SCHULTZ, RA

SEKHON, GS

FRIEDBERG, EC

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT GENET,STANFORD,CA 94305

[2] STANFORD UNIV,MED CTR,SCH MED,DEPT PATHOL,STANFORD,CA 94305

[3] UNIV MARYLAND,DIV HUMAN GENET,BALTIMORE,MD 21201

[4] UNIV WISCONSIN,DIV CLIN GENET,MADISON,WI 53705

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1990年 / 16卷 / 04期

关键词：

D O I：

10.1007/BF01232467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenotypic complementation of xeroderma pigmentosum group A (XP-A) cells by microcell-mediated transfer of a single rearranged neo-tagged human chromosome from a human-mouse somatic cell hybrid designated K3SUB1A9-3 was reported previously. Extended growth of this human-mouse hybrid in culture led to deletion of the small arm of the human chromosome, with concomitant loss of complementing ability when introduced into XP-A cells by microcell-mediated chromosome transfer. Cytogenetic analysis of both hybrids suggests that the complementing locus is on chromosome 9q22.2-q34.3, and Southern blot analysis confirms the presence of distal chromosome 9q sequences. © 1990 Plenum Publishing Corporation.

引用

页码：395 / 400

页数：6

共 24 条

[1] XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP XP-I WITHDRAWN
BOOTSMA, D
KEIJZER, W
JUNG, EG
BOHNERT, E
[J]. MUTATION RESEARCH, 1989, 218 (02): : 149 - 151
[2] CLEAVER JE, 1983, METABOLIC BASIS INHE, P1227
[3] DAIGER SP, 1984, AM J HUM GENET, V36, P736
[4] ELHEFNAWI H, 1965, ANN HUM GENET, V28, P273
[5] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY
FEINBERG, AP
VOGELSTEIN, B
[J]. ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) : 6 - 13
[6] FRIEDBERG EC, 1985, DNA REPAIR, P505
[7] INACTIVATION OF A TRANSFECTED GENE IN HUMAN-FIBROBLASTS CAN OCCUR BY DELETION, AMPLIFICATION, PHENOTYPIC SWITCHING, OR METHYLATION
GEBARA, MM
DREVON, C
HARCOURT, SA
STEINGRIMSDOTTIR, H
JAMES, MR
BURKE, JF
ARLETT, CF
LEHMANN, AR
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (04) : 1459 - 1464
[8] HENNING K, 1989, J CELL BIOCHEM, V3, P52
[9] JOHNSON RT, 1989, HUM GENET, V81, P203
[10] JUNNIUEN C, 1989, CYTOGENET CELL GENET, V51, P226

← 1 2 3 →