FUNCTIONAL-GROUP CONTRIBUTIONS TO THE RETENTION OF ANALYTES IN REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：41

作者：

SMITH, RM

机构：

[1] Department of Chemistry, Loughborough University of Technology, Loughborough

来源：

JOURNAL OF CHROMATOGRAPHY A | 1993年 / 656卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(93)80811-L

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The application of functional group contributions (tau values) to the understanding of the retention of analytes in highperformance liquid chromatography is examined. Group contributions from a range of analytes are compared and their relationship to Hansch substituent constants (pi values) determined. The effects of interactions between groups in polyfunctional analytes and of changes in the organic modifier and composition of the mobile phase are studied and the influence of different stationary phase materials compared. The potential of functional group contribution values for the prediction of relative and absolute retention is examined.

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页码：381 / 415

页数：35

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