METHAMPHETAMINE-INDUCED NUCLEAR C-FOS IN RAT-BRAIN REGIONS

被引：50

作者：

UMINO, A ^{[1
]}

NISHIKAWA, T ^{[1
]}

TAKAHASHI, K ^{[1
]}

机构：

[1] NATL CTR NEUROL & PSYCHIAT, NATL INST NEUROSCI, DEPT MENTAL DISORDER RES, KODAIRA, TOKYO 187, JAPAN

来源：

NEUROCHEMISTRY INTERNATIONAL | 1995年 / 26卷 / 01期

关键词：

D O I：

10.1016/0197-0186(94)00096-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To explore the possible robust changes in neuronal activity in dopamine-poor brain regions after an indirect dopamine agonist, methamphetamine, we have investigated its effects on c-fos expression in rat brain using immunocytochemistry of c-Fos. Intraperitoneal injection of methamphetamine (1.6-4.8 mg/kg), but not of saline, induced a widespread nuclear c-Fos-like immunoreactivity in the pyriform cortex and olfactory tubercle with greatest density followed by the II-VI layers of the neocortex, amygdala, hypothalamus, thalamus, nucleus accumbens and striatum. These expression patterns resemble those elicited by amphetamine and suggest that not only the dopamine-rich subcortical regions but also the cerebral cortex may play a crucial role in behavioral abnormality induced by methamphetamine.

引用

页码：85 / 90

页数：6

共 19 条

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[2]

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