TYPE-1 PROPHOSPHOLIPASE A(2) PROPEPTIDE IN ACUTE LUNG INJURY

被引：46

作者：

RAE, D

PORTER, J

BEECHEYNEWMAN, N

SUMAR, N

BENNETT, D

HERMONTAYLOR, J

机构：

[1] ST GEORGE HOSP,SCH MED,DEPT SURG,LONDON SW17 0RE,ENGLAND

[2] ST GEORGE HOSP,SCH MED,INTENS CARE UNIT,LONDON SW17 0RE,ENGLAND

来源：

LANCET | 1994年 / 344卷 / 8935期

关键词：

D O I：

10.1016/S0140-6736(94)90291-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neutrophil sequestration and activation in the pulmonary vasculature and interstitium are important in acute lung injury. Phospholipase A(2) plays an important part in the production of potent inflammatory mediators in this syndrome. We used our ELISA for type 1 prophospholipase A(2) activation peptides, which have the aminoacid sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR), to show that DSGISPR concentrations in plasma and urine are a sensitive and specific marker of acute lung injury in patients admitted to intensive care. The detection of DSGISPR in the plasma of 11 of 50 unselected patients had a sensitivity of 100% and a specificity of 93% for the presence or future development of acute lung injury.

引用

页码：1472 / 1473

页数：2

共 10 条

[1] PLATELET-ACTIVATING-FACTOR MEDIATES HEMODYNAMIC-CHANGES AND LUNG INJURY IN ENDOTOXIN-TREATED RATS [J].