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QUALITY-CONTROL IN THE SECRETORY PATHWAY

被引：552
作者：
HAMMOND, C
HELENIUS, A
机构：
[1] Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511
来源：
CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 04期
关键词：
D O I：
10.1016/0955-0674(95)80009-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Whereas newly synthesized proteins that have aquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called 'quality control', have been illuminated by recent studies.
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页码：523 / 529
页数：7
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