FENFLURAMINE METABOLISM

被引：58

作者：

BRUCE, RB

MAYNARD, WR

机构：

[1] Research Laboratories, A. H. Robins Company, Inc., Richmond, Virginia

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 07期

关键词：

Blood levels—fenfluramine; Fenfluramine—metabolism; GLC—analysis; m‐Trifluoromethylhippuric acid; de‐ethylated fenfluramine—metabolites; Urinary excretion—fenfluramine and metabolites;

D O I：

10.1002/jps.2600570717

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The metabolism of fenfluramine in man results in the excretion of unchanged fenfluramine, deethylated fenfluramine, and m‐trifluoromethylhippuric acid. Methods are described for the determinations of these three compounds and the total metabolites in urine by GLC. The m‐trifluoromethylhippuric acid accounts for 66 to 93 percent of the dose and 79 to 100 percent of the dose may be accounted for as these three metabolites. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1173 / &