PEPTIDE HISTIDINE METHIONINE (PHM) INCREASES VAGINAL BLOOD-FLOW IN NORMAL WOMEN

被引：8

作者：

PALLE, C

BREDKJAER, HE

OTTESEN, B

FAHRENKRUG, J

机构：

[1] BISPEBJERG HOSP, DEPT GYNAECOL, DK-2400 COPENHAGEN, DENMARK

[2] HVIDOVRE UNIV HOSP, DEPT GYNAECOL & OBSTET, DK-2650 HVIDOVRE, DENMARK

来源：

PEPTIDES | 1990年 / 11卷 / 03期

关键词：

PHM; Vaginal blood flow; Vasodilation;

D O I：

10.1016/0196-9781(90)90035-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of increasing doses of PHM given subepithelially or intravenously on vaginal blood flow was studied. Vaginal blood flow was measured by a heated oxygen electrode, and the concentration of PHM in peripheral plasma was monitored radioimmunochemically. Injection of PHM induced a significant dose-dependent increase in vaginal blood flow. The flow values correlated with the plasma concentrations independent of the way of administration. The efficacy was the same as previously found for VIP but the potency of subepithelially injected PHM was found to be 10-fold lower than that of VIP. In conclusion, PHM and VIP seem to have similar vasodilatory effects upon vaginal blood flow. © 1990.

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收藏

页码：401 / 404

页数：4

相关论文

共 24 条

[1] PEPTIDES PHI AND VIP - COMPARISON BETWEEN VASCULAR AND NONVASCULAR SMOOTH-MUSCLE EFFECT IN RABBIT UTERUS [J].

BARDRUM, B ;

OTTESEN, B ;

FAHRENKRUG, J .

AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (01) :E48-E51

[2] PORCINE PEPTIDE HAVING N-TERMINAL HISTIDINE AND C-TERMINAL ISOLEUCINE AMIDE (PHI) - VASOACTIVE INTESTINAL PEPTIDE (VIP) AND SECRETIN-LIKE EFFECTS IN DIFFERENT TISSUES FROM THE RAT [J].

BATAILLE, D ;

GESPACH, C ;

LABURTHE, M ;

AMIRANOFF, B ;

TATEMOTO, K ;

VAUCLIN, N ;

MUTT, V ;

ROSSELIN, G .

FEBS LETTERS, 1980, 114 (02) :240-242

[3] DISTRIBUTION OF PEPTIDE HISTIDINE ISOLEUCINE IN THE MAMMALIAN RESPIRATORY-TRACT AND SOME ASPECTS OF ITS PHARMACOLOGY [J].

CHRISTOFIDES, ND ;

YIANGOU, Y ;

PIPER, PJ ;

GHATEI, MA ;

SHEPPARD, MN ;

TATEMOTO, K ;

POLAK, JM ;

BLOOM, SR .

ENDOCRINOLOGY, 1984, 115 (05) :1958-1963

[4] STUDIES ON THE DISTRIBUTION OF PHI IN MAMMALS [J].

CHRISTOFIDES, ND ;

POLAK, JM ;

BLOOM, SR .

PEPTIDES, 1984, 5 (02) :261-266

[5] COSECRETION OF PEPTIDE HISTIDINE METHIONINE (PHM) AND VASOACTIVE-INTESTINAL-PEPTIDE (VIP) IN PATIENTS WITH VIP-PRODUCING TUMORS [J].

FAHRENKRUG, J ;

PEDERSEN, JH .

PEPTIDES, 1986, 7 (05) :717-721

[6] DEVELOPMENT AND VALIDATION OF A SPECIFIC RADIOIMMUNOASSAY FOR PHI IN PLASMA [J].

FAHRENKRUG, J ;

PEDERSEN, JH .

CLINICA CHIMICA ACTA, 1984, 143 (03) :183-192

[7]

FAHRENKRUG J, 1987, SCAND J CLIN LAB INV, V47, P43

[8] OCCURRENCE OF VIP AND PEPTIDE HM IN HUMAN-PANCREAS AND THEIR INFLUENCE ON PANCREATIC ENDOCRINE SECRETION IN MAN [J].

FAHRENKRUG, J ;

PEDERSEN, JH ;

YAMASHITA, Y ;

OTTESEN, B ;

HOKFELT, T ;

LUNDBERG, JM .

REGULATORY PEPTIDES, 1987, 18 (01) :51-61

[9] INFUSION OF VASOACTIVE INTESTINAL POLYPEPTIDE IN MAN - PHARMACOKINETICS AND EFFECT ON GASTRIC-ACID SECRETION [J].

HOLMBENTZEN, M ;

CHRISTIANSEN, J ;

PETERSEN, B ;

FAHRENKRUG, J ;

SCHULTZ, A ;

KIRKEGAARD, P .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1981, 16 (03) :429-432

[10] VIP AND PHI IN THE PIG PANCREAS - COEXISTENCE, CORELEASE, AND COOPERATIVE EFFECTS [J].

HOLST, JJ ;

FAHRENKRUG, J ;

KNUHTSEN, S ;

JENSEN, SL ;

NIELSEN, OV ;

LUNDBERG, JM ;

HOKFELT, T .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (02) :G182-G189