SYSTEMIC FLUCONAZOLE THERAPY AND INVITRO ADHESION OF CANDIDA-ALBICANS TO HUMAN BUCCAL EPITHELIAL-CELLS

被引：25

作者：

DARWAZEH, AMG ^{[1
]}

LAMEY, PJ ^{[1
]}

LEWIS, MAO ^{[1
]}

SAMARANAYAKE, LP ^{[1
]}

机构：

[1] UNIV GLASGOW,GLASGOW DENT HOSP & SCH,DEPT ORAL MED & PATHOL,378 SAUCHIEHALL ST,GLASGOW G2 3JZ,SCOTLAND

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 1991年 / 20卷 / 01期

关键词：

ADHESION; CANDIDA-ALBICANS; FLUCONAZOLE;

D O I：

10.1111/j.1600-0714.1991.tb00881.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The adhesion of Candida albicans to buccal epithelial cells (BEC) from four healthy dentate men was studied in vitro 1 wk before, during and after a course of systemic fluconazole (50 mg once daily for 1 wk). After 1 wk of fluconazole intake candidal adhesion to BEC was significantly reduced and this reduction persisted for a week following completion of therapy. Fluconazole, therefore, in addition to being an effective antifungal agent may also have a sustained action on reducing adherence of candidal species to the oral mucosa.

引用

页码：17 / 19

页数：3

共 17 条

[1]

Brammer K. W., 1987, Recent trends in the discovery, development and evaluation of antifungal agents., P141

[2] FLUCONAZOLE IN THE TREATMENT OF CANDIDA-ASSOCIATED DENTURE STOMATITIS [J].

BUDTZJORGENSEN, E ;

HOLMSTRUP, P ;

KROGH, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (12) :1859-1863

[3]

DUPONT B, 1988, J MED VET MYCOL, V26, P67

[4]

FARROW P, 1987, LEVELS FLUCONAZOLE S

[5]

Kennedy M J, 1988, Curr Top Med Mycol, V2, P73

[6] ADHERENCE OF CANDIDA-ALBICANS TO HUMAN BUCCAL EPITHELIAL-CELLS [J].

KIMURA, LH ;

PEARSALL, NN .

INFECTION AND IMMUNITY, 1978, 21 (01) :64-68

[7] TREATMENT OF CANDIDAL LEUKOPLAKIA WITH FLUCONAZOLE [J].

LAMEY, PJ ;

LEWIS, MAO ;

MACDONALD, DG .

BRITISH DENTAL JOURNAL, 1989, 166 (08) :296-298

[8]

MACURA AB, 1988, MYCOSES, V31, P371, DOI 10.1111/j.1439-0507.1988.tb04433.x

[9]

Marriott M. S., 1987, Recent trends in the discovery, development and evaluation of antifungal agents., P81

[10]

MARTIN MV, 1989, J MED VET MYCOL, V27, P63

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