DISULFIDE BRIDGES IN HUMAN-COMPLEMENT COMPONENT C3B

被引：27

作者：

DOLMER, K ^{[1
]}

SOTTRUPJENSEN, L ^{[1
]}

机构：

[1] AARHUS UNIV,DEPT MOLEC BIOL,CF MOLLERS ALLE BLDG 130,DK-8000 AARHUS,DENMARK

来源：

FEBS LETTERS | 1993年 / 315卷 / 01期

关键词：

PLASMA PROTEIN; COMPLEMENT C3; DISULFIDE BRIDGE; SEQUENCE HOMOLOGY; ALPHA-2-MACROGLOBULIN SUPERFAMILY;

D O I：

10.1016/0014-5793(93)81139-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The disulfide bridges of human complement component C3b, derived from C3 by removal of the 77-residue C3a, have been determined. The 10 bridges are Cys537-Cys794, Cys605-Cys640, Cys851-Cys1491, Cys1079-Cys1136, Cys1336-Cys1467, Cys1367-Cys1436, Cys1484-Cys1489, Cys1496-Cys1568, Cys1515-Cys1639, and Cys1615-Cys1624. Including the 3 bridges in C3a (Cys670-Cys698, Cys672-Cys705, and Cys685-Cys706) previously determined by high-resolution X-ray crystallography [Hoppe-Seyler's Z. Physiol. Chem. 361 (1980) 1389 13991 all disulfide bridges of C3 are localized. C3 and the strongly related C4 and C5 are members of the alpha2-macroglobulin superfamily. The predicted bridge patterns of C4 and C5 are discussed and compared with that of alpha2-macroglobulin.

引用

页码：85 / 90

页数：6

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