RECOVERY FROM DEPRESSION AFTER ELECTROCONVULSIVE-THERAPY IS ACCOMPANIED BY EVIDENCE OF INCREASED TETRAHYDROBIOPTERIN-DEPENDENT HYDROXYLATION

被引：42

作者：

ANDERSON, DN

WILKINSON, AM

ABOUSALEH, MT

BLAIR, JA

机构：

[1] CLATTERBRIDGE HOSP,DEPT PSYCHIAT,WIRRAL,MERSEYSIDE,ENGLAND

[2] UNITED ARAB EMIRATES UNIV,FAC MED & HLTH SCI,DEPT PSYCHIAT,AL AIN,U ARAB EMIRATES

[3] UNIV ASTON,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1994年 / 90卷 / 01期

关键词：

PHENYLALANINE; TYROSINE; TETRAHYDROBIOPTERIN; DEPRESSION; ELECTROCONVULSIVE THERAPY;

D O I：

10.1111/j.1600-0447.1994.tb01547.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Serum phenylalanine and tyrosine levels were measured in 26 patients with severe depression before and after receiving electroconvulsive therapy. The phenylalanine:tyrosine [P:T] ratio declined significantly for those responding to treatment but not for nonresponders. These findings are discussed in relation to tetrahydrobiopterin, the essential cofactor for the formation of noradrenaline, dopamine and serotonin and the hydroxylation of phenylalanine to tyrosine.

引用

页码：10 / 13

页数：4

共 23 条

[1] INFLUENCE OF DIETARY DEPRIVATIONS ON PLASMA CONCENTRATION OF FREE AMINO ACIDS OF MAN [J].