MICRODIALYSIS SAMPLING OF THE NEURONAL ENVIRONMENT IN BASIC AND CLINICAL RESEARCH

被引：32

作者：

HAMBERGER, A

JACOBSON, I

NYSTROM, B

SANDBERG, M

机构：

[1] Institute of Neurobiology, University of Göteborg, Göteborg

来源：

JOURNAL OF INTERNAL MEDICINE | 1991年 / 230卷 / 04期

关键词：

AMINO ACIDS; EPILEPSY; HYPOGLYCEMIA; ISCHEMIA; MICRODIALYSIS; NEUROTRANSMITTERS;

D O I：

10.1111/j.1365-2796.1991.tb00460.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Microdialysis is a technique for sampling extracellular fluid (ECF) which has been employed in brain research for about 10 years, and is now in experimental and clinical use in a number of biomedical disciplines. We report on microdialysis of neuroactive amino acids in the central nervous system (CNS) and discuss some technical problems of microdialysis, such as tissue reactions, calibration and the difficulties involved, as well as strategies for determination of the true extracellular concentration of various compounds. Possible mechanisms of nerve cell death in ischaemia and hypoglycaemia are among the factors that have been elucidated using data obtained by microdialysis. The neuronal environment overflows with excitatory amino acids both in brain ischaemia and in hypoglycaemia.

引用

页码：375 / 380

页数：6

共 38 条

[1] POSTNATAL-DEVELOPMENT OF SYNAPTIC GLYCINE RECEPTORS IN NORMAL AND HYPERGLYCEMIC RATS [J].