SPECIFIC IMMUNE-RESPONSE IN THE HUMAN RESPIRATORY-TRACT FOLLOWING ORAL IMMUNIZATION WITH LIVE TYPHOID VACCINE

被引：24

作者：

FORREST, BD

LABROOY, JT

ROBINSON, P

DEARLOVE, CE

SHEARMAN, DJC

机构：

[1] UNIV ADELAIDE,DEPT MED,ADELAIDE,SA 5001,AUSTRALIA

[2] ROYAL ADELAIDE HOSP,DEPT THORAC MED,ADELAIDE,SA 5000,AUSTRALIA

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 03期

关键词：

D O I：

10.1128/IAI.59.3.1206-1209.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Specific antibody responses in the lower respiratory tract of human subjects to orally administered Salmonella typhi Ty21a are reported. These responses, predominantly of the immunoglobulin G class, were determined to be a transudate from serum. These results were supported by the similarity in responses to parenteral administration of heat-killed typhoid vaccine. Specific immunoglobulin A antibody was a poor contributor to the respiratory antibody response to either vaccine.

引用

页码：1206 / 1209

页数：4

共 17 条

[1]

BARTHOLOMEUSZ RCA, 1989, J GASTROENT HEPATOL, V1, P61

[2]

DAVIS GS, 1982, AM REV RESPIR DIS, V126, P611

[3] CONSTRUCTION OF A POTENTIAL BIVALENT VACCINE STRAIN - INTRODUCTION OF SHIGELLA-SONNEI FORM-I ANTIGEN GENES INTO THE GALE SALMONELLA-TYPHI TY21A TYPHOID VACCINE STRAIN [J].