LONG-TERM SEROTONIN REINNERVATION OF THE SUPRACHIASMATIC NUCLEUS AFTER 5,7-DIHYDROXYTRYPTAMINE AXOTOMY IN THE ADULT-RAT

被引：19

作者：

BOSLER, O

VUILLONCACCIUTTOLO, G

SAIDI, H

机构：

[1] Equipe de Neuromorphologie Fonctionnelle, Laboratoire de Neurobiologie, CNRS, Marseille

来源：

NEUROSCIENCE LETTERS | 1992年 / 143卷 / 1-2期

关键词：

SEROTONIN, 5,7-DIHYDROXYTRYPTAMINE; REGENERATION; PLASTICITY; SUPRACHIASMATIC NUCLEUS;

D O I：

10.1016/0304-3940(92)90256-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We present here immunohistochemical evidence that serotonin (5-HT) reinnervation in the suprachiasmatic nucleus (SCN) of adult rats, after intraventricular administration of 5,7-dihydroxytryptamine, is more extensive than formerly believed. The first fibers appeared at 4 months and developed until more than 7 months. However, comparison with age-matched controls showed that, even 24 months post-lesion, the density of 5-HT innervation remained abnormally low. At the electron microscopic level, many synaptic contacts were found to have been re-established. The cellular mechanisms possibly responsible for incomplete 5-HT reinnervation in the SCN are discussed.

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收藏

页码：159 / 163

页数：5

相关论文

共 22 条

[1] AUTORADIOGRAPHIC ANALYSIS OF DIFFERENTIAL ASCENDING PROJECTIONS OF DORSAL AND MEDIAN RAPHE NUCLEI IN RAT [J].

AZMITIA, EC ;

SEGAL, M .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 179 (03) :641-667

[2] FURTHER-STUDIES ON CIRCADIAN HORMONE RHYTHMS AFTER LOCAL PHARMACOLOGICAL DESTRUCTION OF THE SEROTONINERGIC INNERVATION OF THE RAT SUPRACHIASMATIC REGION BEFORE THE ONSET OF THE CORTICOSTERONE RHYTHM [J].

BANKY, Z ;

MOLNAR, J ;

CSERNUS, V ;

HALASZ, B .

BRAIN RESEARCH, 1988, 445 (02) :222-227

[3]

BJORKLUND A, 1981, J PHYSIOL-PARIS, V77, P247

[4] REGENERATION OF CENTRAL SEROTONIN NEURONS AFTER AXONAL DEGENERATION INDUCED BY 5,6-DIHYDROXYTRYPTAMINE [J].

BJORKLUND, A ;

NOBIN, A ;

STENEVI, U .

BRAIN RESEARCH, 1973, 50 (01) :214-220

[5] VIP NEURONS AS PRIME SYNAPTIC TARGETS FOR SEROTONIN AFFERENTS IN RAT SUPRACHIASMATIC NUCLEUS - A COMBINED AUTORADIOGRAPHIC AND IMMUNOCYTOCHEMICAL STUDY [J].

BOSLER, O ;

BEAUDET, A .

JOURNAL OF NEUROCYTOLOGY, 1985, 14 (05) :749-763

[6] ULTRASTRUCTURAL RELATIONSHIPS OF SEROTONIN AND GABA TERMINALS IN THE RAT SUPRACHIASMATIC NUCLEUS - EVIDENCE FOR A CLOSE INTERCONNECTION BETWEEN THE 2 AFFERENT SYSTEMS [J].

BOSLER, O .

JOURNAL OF NEUROCYTOLOGY, 1989, 18 (01) :105-113

[7]

BOSLER O, 1988, J COMP NEUROL, V272, P546

[8]

BOSLER O, 1988, SUPPL EUR J NEUR ABS, V7814, P309

[9] ANTI-5-HYDROXYTRYPTAMINE ANTIBODIES - STUDIES ON THEIR CROSS-REACTIVITY INVITRO AND THEIR IMMUNOHISTOCHEMICAL SPECIFICITY [J].

BRAS, H ;

CHAZAL, G ;

DESTOMBES, J ;

PUIZILLOUT, JJ .

EXPERIMENTAL BRAIN RESEARCH, 1986, 63 (03) :627-638

[10] SEROTONIN REINNERVATION OF THE SUPRACHIASMATIC NUCLEUS BY INTRAHYPOTHALAMIC FETAL RAPHE TRANSPLANTS, WITH SPECIAL REFERENCE TO POSSIBLE INFLUENCES OF THE TARGET [J].

DASZUTA, A ;

MAROCCO, C ;

BOSLER, O .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1991, 3 (12) :1330-1337