MODELING THE DEPOSITION OF INHALED POWDERED DRUG AEROSOLS

被引：31

作者：

CLARK, AR ^{[1
]}

EGAN, M ^{[1
]}

机构：

[1] AEA TECHNOL,CONSULTANCY SERV,SRD,RISLEY WA3 6AT,CHESHIRE,ENGLAND

来源：

JOURNAL OF AEROSOL SCIENCE | 1994年 / 25卷 / 01期

关键词：

D O I：

10.1016/0021-8502(94)90189-9

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A computer modelling study of inhaled aerosol transport and deposition, under flow conditions relevant to the use of pharmaceutical dry powder inhalers, has been carried out. Extrathoracic deposition was estimated using a semi-empirical expression developed by Rudolf et al. (1990, J. Aerosol Sci. 21, 403) representing the filtering efficiency of the oropharynx. Lung deposition was investigated using the model of Egan and Nixon (1985, Radiat. Prot. Dosim. 11, 5). Calculations have been performed for several breathing patterns, with peak flow rates ranging from 7.5 to 120 1 min-1. The range of particle diameters included in the simulations covers the typical range of sizes found in powder inhalation aerosols, extending from 0.5 to 30 mum.

引用

页码：175 / 186

页数：12

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