THE DEVELOPMENTAL PATTERN OF BRCA1 EXPRESSION IMPLIES A ROLE IN DIFFERENTIATION OF THE BREAST AND OTHER TISSUES

被引：320

作者：

MARQUIS, ST

RAJAN, JV

WYNSHAWBORIS, A

XU, TJ

YIN, GY

ABEL, KJ

WEBER, BL

CHODOSH, LA

机构：

[1] UNIV PENN, SCH MED, DEPT MOLEC & CELLULAR ENGN, PHILADELPHIA, PA 19104 USA

[2] UNIV PENN, SCH MED, INST HUMAN GENE THERAPY, PHILADELPHIA, PA 19104 USA

[3] UNIV PENN, SCH MED, DEPT INTERNAL MED, PHILADELPHIA, PA 19104 USA

[4] UNIV PENN, SCH MED, DEPT GENET, PHILADELPHIA, PA 19104 USA

[5] UNIV PENN, SCH MED, DIV ENDOCRINOL DIABET & METAB, PHILADELPHIA, PA 19104 USA

[6] NIH, NATL CTR HUMAN GENOME RES, GENET DIS RES LAB, BETHESDA, MD 20892 USA

[7] UNIV MICHIGAN, SCH MED, DEPT HUMAN GENET, ANN ARBOR, MI 48109 USA

来源：

NATURE GENETICS | 1995年 / 11卷 / 01期

关键词：

D O I：

10.1038/ng0995-17

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have examined the developmental expression of the murine breast and ovarian cancer susceptibility gene, Brca1, to investigate its role in the control of cell growth and differentiation. Specifically, we have analysed Brca1 expression during embryonic development, in adult tissues, and during postnatal mammary gland development, particularly in response to ovarian hormones. Our results suggest that Brca1 is expressed in rapidly proliferating cell types undergoing differentiation. In the mammary gland, Brca1 expression is induced during puberty, pregnancy, and following treatment of ovariectomized animals with 17 beta-estradiol and progesterone. These observations imply that Brca1 is involved in the processes of proliferation and differentiation in multiple tissues, notably in the mammary gland in response to ovarian hormones.

引用

页码：17 / 26

页数：10

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