A POTENTIAL ROLE OF CENTRAL A(1) ADENOSINE RECEPTORS IN THE RESPONSES TO HYPOTHALAMIC-STIMULATION IN THE ANESTHETIZED CAT

被引：13

作者：

DAWIDMILNER, MS ^{[1
]}

SILVACARVALHO, L ^{[1
]}

GOLDSMITH, GR ^{[1
]}

SPYER, KM ^{[1
]}

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT PHYSIOL,LONDON NW3 2PF,ENGLAND

来源：

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1994年 / 49卷 / 01期

基金：

英国惠康基金;

关键词：

ADENOSINE; CARDIOVASCULAR CONTROL; HYPOTHALAMIC DEFENSE AREA; CHEMORECEPTOR; BARORECEPTOR;

D O I：

10.1016/0165-1838(94)90016-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In pentobarbitone anaesthetized and paralysed cats the effects of the A(1) adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) have been observed on the presser response to stimulation of the hypothalamic defence area (HDA) and on the effects of baroreceptor and chemoreceptor reflex activation on arterial blood pressure. The administration of DPCPX decreased the magnitude of the HDA presser response and the chemoreceptor induced rise in blood pressure. The fall in blood pressure induced by baroreceptor activation was enhanced to a small yet significant extent. No changes were observed in the tachypnoea evoked by hypothalamic defence area (HDA) stimulation. These results suggest a possible role for central adenosine A(1) receptors in mediating the cardiovascular changes evoked during HDA stimulation.

引用

页码：15 / 19

页数：5

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