CD5 MESSENGER-RNA EXPRESSION AND AUTOANTIBODY PRODUCTION IN EARLY HUMAN B-CELLS IMMORTALIZED BY EBV

被引：32

作者：

PAAVONEN, T

QUARTEYPAPAFIO, R

DELVES, PJ

MACKENZIE, L

LUND, T

YOUINOU, P

LYDYARD, PM

机构：

[1] UNIV COLL & MIDDLESEX SCH MED,DEPT IMMUNOL,LONDON,ENGLAND

[2] BREST UNIV,SCH MED,DEPT IMMUNOL,BREST,FRANCE

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 31卷 / 03期

关键词：

D O I：

10.1111/j.1365-3083.1990.tb02768.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A number of studies have suggested that lymphocytes producing polyreactive antibodies belong to the CD5+ B‐cell subset. In this study we have examined CD5 at the cell surface and mRNA levels in EBV‐driven cord blood and fetal liver clones previously characterized in terms of their antibody specificities. We show that EBV‐immortalized cells can express surface CD5, and that some of the clones not expressing surface CD5 express it at the mRNA level. The complete absence of CD5 mRNA in some polyreactive clones is consistent with the proposition that the production of auto‐antibodies and multispecific antibodies is not restricted to the CD5+ B‐cell subset. Copyright © 1990, Wiley Blackwell. All rights reserved

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页码：269 / 274

页数：6

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