CALCIUM REVEALS DIFFERENT MECHANISMS OF GUANYLATE-CYCLASE ACTIVATION BY ATRIAL-NATRIURETIC-FACTOR AND ATP IN RAT LUNG MEMBRANES

被引:10
作者
CHANG, CH
JIANG, B
DOUGLAS, JG
机构
[1] Department of Medicine, Case Western Reserve University, Cleveland, OH
关键词
CALCIUM ION; GUANYLATE CYCLASE; ATRIAL NATRIURETIC FACTOR; ATP; CYCLIC GMP;
D O I
10.1016/0167-4889(91)90136-L
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
CaCl2 inhibited ATP-stimulated guanylate cyclase activity, but had little effect on basal and atrial natriuretic factor-stimulated guanylate cyclase activity in rat lung membranes. LaCl3 had similar effects as CaCl2 on basal and stimulated guanylate cyclase activity. LiCl and other monovalent salts inhibited ATP-stimulated guanylate cyclase activity more than basal enzyme activity. However, atrial natriuretic factor somehow stabilized the enzyme against the inhibitory effect of LiCl. These results suggest that ATP and atrial natriuretic factor activate the enzyme through different mechanisms. Since the effect of calcium on guanylate cyclase activity is different from that of monovalent salts and can be mimicked by lanthanum, it may be mediated by a specific calcium binding site or binding protein.
引用
收藏
页码:42 / 46
页数:5
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