EVIDENCE FOR SEX STEROID-RECEPTORS IN FELINE BRAIN-STEM

被引：5

作者：

CHRAPUSTA, S

GRIEB, P

机构：

[1] MARIA SKLODOWSKA CURIE MEM CANC CTR, ENDOCRINOL LAB, WARSAW, POLAND

[2] INST ONCOL, PL-02034 WARSAW, POLAND

[3] POLISH ACAD SCI, MED RES CTR, DEPT NEUROPHYSIOL, WARSAW 42, POLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 142卷 / 02期

关键词：

BRAIN-STEM; ANDROGEN RECEPTOR; ESTROGEN RECEPTOR; PROGESTIN RECEPTOR;

D O I：

10.1016/0304-3940(92)90365-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Specific binding sites for estrogens, androgens, and progestins were found in cytosol from perfused cat brainstems with the use of a steroid binding assay. These sites resemble 'classical' steroid receptors in ligand specificity as well as in sedimentation properties (sedimentation constant 8-10S on sucrose density gradient). The presence of estrogen receptor in brainstem extracts was also confirmed by an enzyme immunoassay employing monoclonal antibodies directed against human estrogen receptor. This finding may be relevant to known influences of sex steroids on respiration.

引用

页码：167 / 170

页数：4

共 21 条

[1] PROGESTERONE STIMULATES RESPIRATION THROUGH A CENTRAL-NERVOUS-SYSTEM STEROID RECEPTOR-MEDIATED MECHANISM IN CAT [J].