ASYMMETRIC-SYNTHESIS OF 1-HYDROXYINDOLIZIDINES, BIOSYNTHETIC PRECURSORS TO THE TOXIC INDOLIZIDINE ALKALOIDS SLAFRAMINE AND SWAINSONINE

被引：29

作者：

TAKAHATA, H

BANBA, Y

MOMOSE, T

机构：

[1] Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)80439-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An enantioselective synthesis of 1-hydroxyindolizidines (1 and 2) from racemic N-benzyloxycarbonyl-3-hydroxy-4-pentenylamine (3) by following the Sharpless kinetic resolution, intramolecular amidomercuration, and radical Michael addition as key steps is described. © 1990.

引用

页码：763 / 764

页数：2

共 8 条

[1]

BHIDE R, 1990, TETRAHEDRON LETT, V51, P4827

[2]

GIESE B, 1986, RADICALS ORGANIC SYN, P36

[3] SYNTHESIS AND CONFIGURATIONAL ASSIGNMENT OF OPTICALLY-ACTIVE 1-HYDROXYINDOLIZIDINES [J].