NEW PROGRAMS FOR PROTEIN TERTIARY STRUCTURE PREDICTION

被引：49

作者：

FETROW, JS ^{[1
]}

BRYANT, SH ^{[1
]}

机构：

[1] NIH, NATL LIB MED, NATL CTR BIOTECHNOL INFORMAT, BETHESDA, MD 20894 USA

来源：

BIO-TECHNOLOGY | 1993年 / 11卷 / 04期

关键词：

D O I：

10.1038/nbt0493-479

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Prediction of protein tertiary structure remains an unsolved problem in molecular biology, but a solution to this problem is extremely important for protein engineering and rational drug design. Recent developments in motif recognition and side chain modeling present the prospect of nearly automatic model building for a large fraction of newly determined protein sequences. We review some of these new algorithms and present preliminary results of their application to the prediction of a structure for fasciclin III, a neural adhesion molecule from Drosophila.

引用

页码：479 / 484

页数：6

共 56 条

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