SELECTIVE INDUCTION OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE BY PERFLUORODECANOIC ACID

被引:9
作者
ARAND, M [1 ]
COUGHTRIE, MWH [1 ]
BURCHELL, B [1 ]
OESCH, F [1 ]
ROBERTSON, LW [1 ]
机构
[1] UNIV DUNDEE,INST MED SCI,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
基金
英国惠康基金;
关键词
UDP-GLUCURONOSYLTRANSFERASES; BILIRUBIN GLUCURONIDATION; ENZYME INDUCTION; PERFLUORODECANOIC ACID; PEROXISOME PROLIFERATION;
D O I
10.1016/0009-2797(91)90008-U
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Differential effects of perfluorodecanoic acid (PFDA) on rat liver UDP-glucuronosyltransferase isoenzymes have been observed after a single i.p. administration of the compound to young male Sprague-Dawley rats. (1) Bilirubin glucuronidation was induced 2-fold. The induced state was stable for at least 3 weeks. (2) Glucuronidation of 1-naphthol, morphine and testosterone was decreased to half of the control values. These decreases were maximal after 12 days but all three activities returned to normal levels after 3 weeks. (3) Immunoblotting experiments indicated that the differential effects of PFDA on UDP-glucuronosyltransferase activities were due to modulation of enzyme protein concentrations rather than activation/inactivation mechanisms. With respect to its influence on UDP-glucuronosyltransferase isoenzymes, PFDA may be classified as a clofibrate-type inducer. The persistence of the induction after a single application however is unique among peroxisome proliferators and therefore PFDA may be a useful, elective inducer of bilirubin glucuronidation.
引用
收藏
页码:97 / 105
页数:9
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